Props to Steve in another thread for bringing this resource up. Personally I have been with Aweber since I been online. It was my first autoresponder and so far has never failed me. With the addition of Michael though and the processes of lead acquisition, data management and ultimately selling data it wont be long before we have our own mailing operation.
However for marketers just starting out who are not comfortable dropping money on their autoresponder, you should have a look at Zookoda. I should tell you that I feel it's very basic however will be a great starting point for beginning marketers to get familiar with autoresponders and constructing newsletters.
If you already using Zookoda or you decide to give it a test drive, keep us updated.
Zookoda ->
http://www.zookoda.com/